Cinnamyl Alcohol: Natural Products of Antioxidants

Health medical experts say that many human diseases are caused by the oxidation of body cells and the increase of oxidizing substances in the body. The phenomenon of reactive oxygen damage to cells is called cell oxidation. Oxidation affects cells all the time. Not only exogenous oxidants can cause the accumulation of reactive oxygen species in the cells, but also the production of reactive oxygen species in the process of aerobic metabolism of the cells themselves. Reactive oxygen species have a high biological activity, are easily reacted with biological macromolecules, and directly damage or damage a wide range of biological structures through a series of over-oxidation chain reactions. Oxidation is caused by disorders in the production and scavenging of free radicals by cells of the body and can cause neurological diseases such as stroke, Parkinson's disease, and Alzheimer's disease. It is also associated with the pathological pathways of other diseases, such as heart disease, autoimmune diseases, tumors, and viral diseases (such as AIDS, hepatitis).

The search for new antioxidants has become an effective way to treat various diseases caused by oxidation, so the study of antioxidants is also one of the important directions for the treatment of diseases to prolong life. The rapid screening of high-efficiency and low-toxicity antioxidants, especially natural products or derivatives with natural products as skeletons, is a shortcut to develop new drugs for the mechanism of action of antioxidants.

A number of experimental studies in Zhejiang Institute of Medicine have shown that cinnamyl alcohol has anti-oxidation and scavenging activity on free radicals; inhibition of platelet aggregation induced by adenosine diphosphate ADP; and anti-cancer effect, can be used as tumor chemistry Effective substances that prevent substances and other activities. And cinnamyl alcohol has the unique advantage that it exists in natural plants, does not contain harmful substances, and its activity is very stable. The Institute conducted a relevant test on cinnamyl alcohol, and its antioxidant activity in vitro for scavenging superoxide anion radicals and inhibiting free radical-induced lipoperoxidation. The test results showed that cinnamyl alcohol has the antioxidant activity of eliminating superoxide radical activity, scavenging free radicals, and inhibiting free radical-induced production of lipoperoxide. It can be expected to develop into a disease that prevents the production of free radicals during pathological changes, including inflammatory diseases, Diseases such as autoimmune diseases, radiation therapy sequelae, tumors, myocardial ischemia, cardiac hypertrophy, aging, atherosclerosis, and diseases caused by xanthine oxidase include drug compositions of gout.